胰岛素样生长因子-2、血管内皮生长因子受体-2、血小板源生长因子受体和类肝素酶-1在肾上腺皮质癌中的表达及其意义

Relationship of IGF-2,VEGFR-2,PDGFR and HPA expressions in adrenal cortical carcinoma

目的探讨胰岛素样生长因子-2(IGF-2)、血管内皮生长因子受体-2(VEGFR-2)、血小板源生长因子受体(PDGFR)和类肝素酶-1(HPA)在肾上腺皮质癌(ACC)中的表达及其临床意义。方法选取经手术治疗且具有完整的临床、病理资料的肾上腺皮质肿瘤存档石蜡标本37例,其中良性组20例,恶性组(ACC组)17例。采用免疫组化技术检测良、恶性肾上腺皮质肿瘤中IGF-2、VEGFR-2、PDGFR和HPA的表达情况。结果 IGF-2在ACC组中呈高表达(76.47%),在良性组中表达低(5.00%),ACC组与良性组之间IGF-2的表达有极显著性差异(P<0.01);VEGFR-2在ACC组中呈高表达(76.47%),在良性组中表达较低(25.00%),ACC组与良性组之间VEGFR-2的表达有显著性差异(P<0.05);PDGFR在ACC组中表达的阳性率为(17.64%),在良性组中为(20.00%),PDGFR在ACC组中的表达与在良性组中的表达无显著性差异(P>0.05)。HPA在ACC组中的表达为(94.12%),良性组中为(15.00%),两者之间有显著性差异(P<0.05)。结论 IGF-2、VEGFR-2和HPA在ACC中的高表达为抗肿瘤血管生成治疗在ACC中的应用,提供了相应的理论依据。

Objective To investigate the expressions of IGF-2,VEGFR-2,PDGFR and HPA in adrenal cortical carcinoma（ACC） and to discuss their clinical significance.Methods 37 patients were divided into two groups,20 in the benign group and 17 in the malignant group（adrenal cortical carcinoma,ACC group）.The adrenal cortical neoplasm specimens removed from these patients were examined with immunohistochemistrical method to detect the expressions of IGF-2,VEGFR-2,PDGFR and HPA.Results IGF-2,VEGFR-2,and HPA expressed highly in the ACC group（76.47%,76.47%,and 94.12% respectively） and lowly in the benign group（5.00%,25.00%,and 15.00% respectively）,with significant difference（P0.05）.PDGFR expressions were not significantly different between the ACC group and benign group（P0.05）.Conclusion The high expressions of IGF-2,VEGFR-2,and HPA in ACC contribute to tumor angiogenesis,which provide theoretical evidences for anti-angiogenesis regime of ACC.