善释Ⅱ组织补片使用效果的研究

Research on the Effects of Shanshi Ⅱ Tissue Mesh

目的研究善释Ⅱ组织补片在植入肌体后的局部组织反应及对腹壁缺损的修复效果,并比较其与另两种不同成分补片的效果差异。方法将实验家兔分为三组,于下腹正中处切开,在腹膜外分别植入善释Ⅱ组织补片、善释聚丙烯补片和超普补片。日常观察腹壁缺损修复情况,数周后取出补片及修补处组织,观察补片皱缩和组织病理反应。结果采用善释Ⅱ补片的实验组较之对照组能够更好的增强腹壁的顺应性,补片皱缩率小,组织炎性反应显著减弱。结论减少补片中的聚丙烯含量,添加可降解的聚乙交-己内酯成分能够有效地改善补片的修复效果,降低术后组织炎性反应及纤维化程度。

Objective To study the effects of Shanshi Ⅱ mesh to repair abdominal trauma and the tissue reaction after embedding.Compare the effects with other 2 kinds of mesh.Method The rabbits were divided to 3 groups.The model of abdominal hernia was established by surgery and 3 kinds of mesh（Shanshi Ⅱ,Shanshi PP,chaopu） were planted in 3 groups.The mesh and the tissues that surrounded the mesh were taken out after several weeks.Pathological reaction were observed and shrinking rate of each group were calculated.Results The mesh of Shanshi Ⅱ can improve the adaptability of abdominal muscles.The shrinking rate and the inflammatory reaction is lower comparing with the control group.Conclusion Reducing the content of polypropylene in mesh and adding degradable poly（glycolide-co-e-caprolactone）（PGCL） can improve the effects of repair of mesh and restrain inflammatory reaction and fibrosis.