营养与病毒感染性疾病动物模型

Nutrition and Animal Models of Virus Infection

当前新现病毒性疾病的研究最大的"瓶颈"在于没有胜任动物模型。建立在非人灵长类动物基础上的模型,虽然可以部分复制人类疾病特征,但其经济性欠佳且与动物权益的保护有所冲突;而啮齿类动物对新现病毒的易感性往往较低,也不能很好地复制人类疾病。本文对营养、免疫及疾病易感性关系研究的进展进行文献回顾,以发现解决当前难题的线索。

The studies on emerging viral diseases are restrained by a ＂bottle neck＂： no competent animal model available.Models based on nonhuman primates have similar clinical manifestations to human diseases;however,it is uneconomic to construct such models.Furthermore,there is a controversy about protection of animal rights.Models based on rodents are often incompetent due to their low susceptibility for those viruses.This brief review focuses on the current studies on relations among nutrition,immunity and susceptibility to give insights in overcoming conundrums.