雷帕霉素药物洗脱支架置入前后稳定型心绞痛患者血清CXC趋化因子16的变化

Changes of serum CXC-chemokine ligand 16 in stable angina pectoris patients before and after implantation with rapamycin eluting stent

背景:CXC趋化因子16作为一种炎症反应中的趋化因子冠状动脉粥样硬化发生机制中发挥重要作用。目的:观察雷帕霉素药物洗脱支架置入前后稳定型心绞痛患者血清中CXC趋化因子16的变化。方法:选择郑州大学第一附属医院心内科住院行冠状动脉支架置入并置入1或2枚雷帕霉素药物洗脱支架的稳定型心绞痛患者40例,另选同期于本院经冠状动脉造影显示无异常的健康者10名作为对照组。对受试者进行CXC趋化因子16、超敏C-反应蛋白检测,并分析其相互关系。结果与结论:与对照组相比,血清CXC趋化因子16在支架置入前、置入后0.5,2,24h均升高(P<0.05);与置入前相比,置入后0.5,2h升高(P<0.01)。置入后0.5,2,24h患者血清超敏C-反应蛋白较对照组显著升高(P<0.01),其中置入后0.5h与2h差异无显著性意义(P>0.05),2h高于24h(P<0.01)。血清CXC趋化因子16和超敏C-反应蛋白水平呈正相关性(r=0.632,P=0.017)。

BACKGROUND：CXC-chemokine ligand 16（CXCL16） is an important chemokine involved in inflammatory reaction,and plays a key role in the occurrence of coronary atherosclerosis. OBJECTIVE：To investigate the changes of serum CXCL16 in stable angina pectoris（SAP） patients who were implanted with rapamycin eluting stent. METHODS：Forty SAP patients were selected from the Department of Cardiology,the First Affiliated Hospital of Zhengzhou University. They underwent implantation of one or two rapamycin eluting stents. Another 10 health persons confirmed by coronary angiography were selected as controls. Serum CXCL16 and high-sensitivity C-reactive protein（Hs-CRP） were studied in all the subjects. RESULTS AND CONCLUSION：Compared with the control group,the serum CXCL16 showed higher levels in SAP patients prior to stent implantation and 0.5,2,24 hours after stent implantation（P 0.05）;the serum CXCL16 level increased at 0.5 and 2 hours after stent implantation compared with before stent implantation（P 0.01） . At 0.5,2 and 24 hours after stent implantation,the levels of Hs-CRP in the SAP group were significantly higher than those in the control group（P 0.01）;no significant difference in Hs-CRP levels was found（P 0.05） ,while the level of Hs-CRP at 2 hours was higher than that at 24 hours（P 0.05） . Serum CXCL16 is positively correlated with Hs-CRP（r=0.632,P=0.017）.