摘要
为了研究蜜蜂巢脾对急性炎症模型动物的影响,作者以中蜂巢脾和意蜂巢脾为材料,水提法处理样品,研究其对二甲苯致小鼠耳肿胀、醋酸致小鼠腹腔毛细血管通透性增强和角叉菜胶致小鼠足肿胀的影响。结果表明,中蜂巢脾水提物和意蜂巢脾水提物均显著抑制二甲苯引起的耳肿胀,显著降低角叉菜胶引起的足肿胀程度和局部炎症组织的PGE2含量,对醋酸致小鼠腹腔毛细血管通透性增强则无抑制作用。此外,中蜂巢脾水提物的抗炎活性表现出剂量依赖效应。
The aim of this study is to explore the pharmacological activities of honeycomb against acute inflammation in animals,for this,the effect of water extracts from Apis cerana cerana honeycomb and A.mellifera ligustica honeycomb on Xylene-induced ear edema,acetic acid-induced vascular permeability and carrageenan-induced hind paw edema tests in mice were investigated.The results showed that both samples exhibited remarkable inhibition in xylene-induced ear edema model,carrageenan-induced hind paw edema model and the content of PGE2 in the inflammatory tissues,while they showed no anti-inflammatory against acetic acid-induced vascular permeability.The pharmacological activities of the water extracts of A.cerana cerana honeycomb show in a concentration-dependent manner.
出处
《食品与生物技术学报》
CAS
CSCD
北大核心
2011年第5期648-652,共5页
Journal of Food Science and Biotechnology
基金
国家蜂产业技术体系建设专项资金项目(NYCYTX-43)
关键词
蜜蜂巢脾
水提液
抗炎
急性炎症
PGE2
honeycomb
water extract
anti-inflammatory
acute inflammation
PGE2
