鹿茸多肽促进皮肤创面愈合的实验研究

Study of Enhancement to Skin Wound Healing by Pilose Antler Polypeptides

目的探讨鹿茸多肽对皮肤愈合的影响。方法设计将48只家兔随机分成1个对照组和3个实验组，每组12只。实验组1单纯肌肉注射用药；实验组2为单纯创口外部用药；实验组3则肌注与外部混合用药。以兔背部以脊柱为中心设计5cm×5cm创面，每日给药1次，分别于2、4,6、8、10、12、14日观察创面的愈合情况；于第10天测量创面大小、计算愈合面积、愈合速度。结果实验组3创面愈合面积、愈合速度均显著高于其它组。结论鹿茸多肽能够提高皮肤愈合速度。

Objective To discuss the influence of Pilose antler polypeptide （PAP） to skin healing; Methods Divide 48 rabbits into 4 groups at random, one contrast group and three experimental groups. Only PAP injection in experimental group 1; only external use of PAP in experimental group 2; mixed usage of PAP in experimental group 3. Design a wound of 5cm in diameter around spine on the back of rabbit. Use medicine once a day and Observe growth of the wound on 2,4,6,8,10,12,14 days, calculate healing area and velocity on 10th day. Results Healing area and velocity of experimental group 3 are higher than other three groups. Conclusion PAP can enhance skin wound healing.