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培美曲塞单药治疗老年晚期结直肠癌患者的临床疗效观察 被引量:2

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摘要 目的观察单药二线培美曲塞治疗老年晚期结直肠癌患者的近期疗效与不良反应。方法对34例接受单药培美曲塞化疗的老年复发晚期结直肠癌患者的临床疗效进行回顾性分析。结果全组34例患者,总有效率(CR+PR)38.24%,不良反应均尚可耐受,发生Ⅲ度和Ⅳ度血液学不良反应者较少。结论老年晚期结直肠癌患者可从单药培美曲塞化疗中获益:培美曲塞不良反应轻。
作者 赵梅 刘峰
出处 《医学信息》 2011年第20期6760-6761,共2页 Journal of Medical Information
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  • 1Richard M G,Neal J M,Josep Tabernero,et al.Accomplishments in 2008 in the treatment of advanced metastatic colorectal cancer[J].Gastrointest Cancer,2009,3(suppl 2):S23-S27.
  • 2Hanna K S,Richard M G.Colorectal cancer treatment in older patients[J].Gastrointestinal cancer research,2007,1:248-253.
  • 3Underhill C,Goldstein D,Gorbounova VA,et al.A randomized phase II trial of pemetrexed plus irinotecan (ALIRI) versus leucovorin-modulated 5-FU plus irinotecan (FOLFIRI) in first-line treatment of locally advanced or metastatic colorectal cancer[J].Oncology.2007,73(1-2):9-20.
  • 4Atkins JN,Jacobs SA,Wieand HS,et al.Pemetrexed/oxaliplatin for first-line treatment of patients with advanced colorectal cancer:a phase II trial of the National Surgical Adjuvant Breast and Bowel Project Foundation Research Program[J].Clin Colorectal Cancer.2005 Sep,5(3):181-187.
  • 5John W,Picus J,Blanke CD,et al.Activity of multitargeted antifolate (pemetrexed disodium,LY231514) in patients with advanced colorectal carcinoma:results from a phase II study[J].Cancer.2000 Apr 15;88(8):1807-1813.
  • 6Hochster H,Kettner E,Kroning H,et al.Phase I/II dose-escalation study of pemetrexed plus irinotecan in patients with advanced colorectal cancer[J].Clin Colorectal Cancer.2005 Nov;5(4):257-562.
  • 7Corrado Pedrazzani,Guido Cerullo,Giovanni De Marco,Daniele Marrelli,Alessandro Neri,Alfonso De Stefano,Enrico Pinto,Franco Roviello.Impact of age-related comorbidity on results of colorectal cancer surgery[J].World Journal of Gastroenterology,2009,15(45):5706-5711. 被引量:5
  • 8Souglakos J,Androulakis N,Syrigos K,et al.FOLFOXIRI(folinic acid,5-fluorouracil,oxaliplatin and irinotecan) VS FOLFIRI (foiinic acid,5-fluorouracil and irinotecan) as first-line treatment in metastatic colorectal cancer (MCC):a multicentre andomised phase Ⅲtrial from the Hellenic Oncology Research Group (HORG)[J].Br J Cancer,2006,94 (6):798-805.
  • 9VareyAH,Rennel ES,Qiu Y,et al.VEGF 165 b,an antiangiogenic VEGF2A isoform,binds and inhibits bevacizumab treatment in experimental colorectal carcinoma:balance of pro-and antiangiogenic VEGF2A isoforms has implications for therapy[J].BrJ Cancer,2008,98:1366-1379.
  • 10van Krieken H,Tol J.Setting future standards for KRAS testing in colorectal cancer[J].Pharmacogenomics,2009,10:1-3.

二级参考文献14

  • 1Richard M G, Neal J M, Josep Tabernero, et al. Accomplishments in 2008 in the treatment of advanced metastatic colorectal cancer [J]. Gastrointest Cancer, 2009, 3(suppl 2):S23-S27.
  • 2Hanna K S, Richard M G. Colorectal cancer treatment in older patients[J]. Gastrointestinal cancer research, 2007, 1 : 248- 253.
  • 3British Colorectal Collaborative Group. Surgery for eolorectal cancer in elderly patients: a systematic review[J]. Lancet, 2000,356 (9234) : 968- 974.
  • 4MeCardle C S, Hole D J. Outcome following surgery for colorectal cancer[J]. Br Med Bull, 2002,64:119-125.
  • 5Lacy A M, Garcia--Valdecasas J C, Delgado S,et al. Laparoscopy -assisted colectomy versus colectomy for treatment of non-metastatic colon cancer: a randomized trial[J]. Lancet, 2002,359:2224-2229.
  • 6Andre T, Boni C, Navarro M, et al. Improved overall survival with oxalipatin, fluorouracil, and leucovorin as adjuvant treatment in stage Ⅱ or Ⅲ colon cancer in the MOSAIC trial[J]. J Clin, 2009, 27: 3109-3116.
  • 7Twelves C. Capecitabine as adjuvant treatment for stage Ⅲ colon cancer[J]. N Engl J Med, 2005,352: 2696-2704.
  • 8Schrag D, Cramer L D,Bach P B, et al. Age and adjuvant chemotherapy use after surgery for stage Ⅲ colon cancer[J]. J Natl Cancer Inst, 2001,93: 850-857.
  • 9Daniel J S, Richard M G, Stacy D J, et al. A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients [J]. N Engl Med,2001, 345(15):1091-1097.
  • 10Folprecht G, Seymour M T, Saltz L, et al. Irinotecan/fluorouracil combination in first-line therapy of older and younger patients with metastatic colorectal cancer: combined analysis of 2,691 patients in randomized controlled trials[J]. J Clin Oncol, 2008,26: 1443-1451.

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