甲状腺癌的分子生物学研究分析
摘要
探讨甲状腺癌的分子生物学研究。本研究列出了多种与甲状腺癌相关的肿瘤标志物,分析了备肿瘤标志物的特性:并论述了Ret/PTC的基因和Ras癌基因同甲状腺癌的关系。完全敏感且特异的针对甲状腺癌某一组织类型的肿瘤标志物尚不十分明确,还需进一步研究才可确定。
出处
《医学信息》
2011年第20期6923-6924,共2页
Journal of Medical Information
参考文献4
-
1陈润成,刘四红,沈樑,梁柳森.CK19 mRNA在甲状腺肿瘤中的表达及意义[J].广州医药,2009,40(6):7-9. 被引量:2
-
2Londero SC,Codballe C,Krogdahl A,et al.Paillary microcarcinoma of the thyroid gland:Is the immunohistochemical expression of cyelin D1 or galectin-3 in primary tumour an indicator of metastatic disease[J].Acta Oncol,2008,47(3):451-457.
-
3Smith VE,Read ML,Turnell AS,et al.A novel mechanism of sodium iodide symporter repression in differentiated thyoid cancer[J].J,Cell Sci,2009,122(18):3303-3402.
-
4Lin CI,Whang EE,Abramson MA,et al.Calectin-3 regulates apoptosis and doxouubicin chemoresistance in papillary thyroid cancer cells[J].Biockem Biophys Res Commun,2009,379(2):629-631.
二级参考文献12
-
1Sahoo S, Hoda SA, Rosai J, et al. Cytokeratin 19 immunoreactivity in the diagnosis of papillary thyroid carcino ma: a note of caution [J] . Am J Clin Pathol, 2001, 116 (5): 696-702.
-
2de Matos PS, Ferreira AP, de Oliveira, et al. Usefulness of HBME, cytokeratin 19 and galectin-3 immunostaining in the diagnosis of thyroid malignancy [ J ] . Histopathology, 2005, 47 (4) : 391-401.
-
3Seiberling KA, Dutra J, Grant T, et al. Role of intrathyroidal calcifications detected on ultrasound as a marker of malignancy [ J] . Laryngoscope, 2004, 114 (10) : 1753-1757.
-
4Mackenzie EJ, Mortimer RH. Thyroid nodules and thyroid cancer [J] . Med J Aust, 2004, 180 (5): 242- 247.
-
5Nix P, Nicolaides A, Coatesworth AP. Thyroid cancer review 1: presentation and investigation of thyroid cancer [J] . Int J Clin Pract, 2005, 59 (11) : 1340-1344.
-
6Finley D J, Zhu B, Barden CB, et al. Discrimination of benign and malignant thyroid nodules by molecular profiling [J] . Ann Surg, 2004, 240 (3): 425-437.
-
7Eldar S, Sabo E, Cohen A, et al. The value of histomorphometric nuclear parameters in the diagnosis of well differentiated follicular carcinomas and follicular adenomas of the thyroid gland [ J] . Histopathology, 1999, 34 (5) : 453-461.
-
8Shin E, Chung WY, Yang WI, et al. RET/PTC and CK19 expression in papillary thyroid carcinoma and its clinicopathologic correlation [ J ] . J Korean Med Sci, 2005, 20 (1): 98-104.
-
9Q Park YJ, Kwak SH, Kim DC, et al. Diagnostic value of galectin-3, HBME-1, cytokeratin 19, high molecular weight cytokeratin, cyclin D1 and p27 (kip 1 ) in the differential diagnosis of thyroid nodules [ J ] . J Korean Med Sci, 2007, 22 (4): 621-628.
-
10Bonzanini M, Amadori PL, Sagramoso C, et al. Expression of eytokeratin 19 and protein p63 in fine needle aspiration biopsy of papillary thyroid carcinoma [ J ] . Acta Cytol, 2008, 52 (5): 541-548.
-
1徐亮,卢光宇.ras癌基因与大肠癌[J].泸州医学院学报,1996,19(4):325-328. 被引量:3
-
2朱人敏,张予蜀.ras癌基因和大肠癌关系的研究[J].江苏医药,1997,23(2):103-105. 被引量:7
-
3李惠芳,周爱儒.ras癌基因族及其产物p21蛋白[J].长治医学院学报,1992,6(1):51-54.
-
4卢锦林.癌基因与口腔肿瘤关系的研究近况[J].广西医学,1998,20(3):396-399.
-
5胡勇,向近敏.ras癌基因研究进展[J].中国肿瘤临床,1991,18(3):187-189. 被引量:4
-
6郁宝铭,赵任.大肠癌分子生物学研究的现状[J].世界华人消化杂志,1999,7(2):173-175. 被引量:13
-
7郑唯强,詹镕洲.乳腺癌分子生物学研究的进展[J].肿瘤防治研究,1994,21(2):128-128.
-
8陈玉泉,陈莉.乳腺癌的分子生物学研究及临床意义[J].外科,1997,2(2):110-113.
-
9田道锋.脑膜瘤分子生物学研究[J].中国临床神经外科杂志,2000,5(3):191-191.
-
10潘瑞蓉,张海鸣,王济芳,龙卫国,钱唯韵,袁国跃,王宏星.RET/PTC3在甲状腺乳头状癌中的表达[J].广东医学,2016,37(4):577-579. 被引量:4