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朊病毒治疗候选药物的研究进展 被引量：7

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摘要 疯牛病（BSE）、羊瘙痒症（scrapie）、人库鲁病（kuru）和人克雅氏症（CJD）等都是由朊病毒（prion）引起的一类具有高度传染性和致死性的中枢神经系统疾病。研究表明,细胞内正常朊病毒（PrPC）是一种广泛地表达于脊椎动物细胞表面的内源性糖基化磷脂酰肌醇锚定蛋白,在体内以单体的形式出现,不具有致病性。
作者 钟正伟 宋有涛
机构地区 辽宁大学生命科学院 承德石油高等专科学校化学工程系 辽宁省动物资源与疫病防治重点实验室
出处 《中国人兽共患病学报》 CAS CSCD 北大核心 2011年第9期828-835,共8页 Chinese Journal of Zoonoses
基金 国家自然科学基金项目(30970125) 教育部人文社会科学研究青年基金(08JC790053) 辽宁省教育厅优秀人才计划(2009R26)
关键词 正常朊病毒 病毒治疗 糖基化磷脂酰肌醇锚定蛋白 中枢神经系统疾病 药物 候选 克雅氏症 人库鲁病
分类号 S852.65 [农业科学—基础兽医学]
  • 相关文献

参考文献32

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  • 2张杰,路伟,刘永生.细胞型朊蛋白(PrP^c)研究进展[J].中国人兽共患病学报,2008,24(1):83-86. 被引量：5
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二级参考文献26

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共引文献4

同被引文献105

  • 1秦晓萍,秦红丽.疯牛病在牛群中的分布特点[J].畜牧兽医科技信息,2003,19(6):25-28. 被引量：2
  • 2李定祥,闵知大.两面针中生物碱的分离[J].中国天然药物,2004,2(5):285-288. 被引量：24
  • 3李文哲,芦洁,孙晓宇,汪世龙,倪亚明,朱文斯.几种中药提取物和药物对乙醇脱氢酶活性影响的研究[J].中药材,2006,29(8):816-818. 被引量：22
  • 4张太翔,赵德明.传染性海绵状脑病传播途径的研究进展[J].中国畜牧兽医,2007,34(1):123-125. 被引量：2
  • 5Prusiner SB. Biology of prion diseases. J Acquir Immune Defic Syndr, 1993, 6(6): 663-665.
  • 6Ghaemmaghami S, May BCH, Renslo AR, et al. Discovery of 2-aminothiazoles as potent antiprion compounds. J Virol, 2010, 84(7): 3408-3412.
  • 7Sim VL, Caughey B. Recent advances in prion chemotherapeutics. Infect Disord Drug Targets, 2009, 9(1): 81-91.
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  • 9Bach S, Talarek N, Andrieu T, et al. Isolation of drugs active against mammalian prions using ayeast-based screening assay. Nat Biotechnol, 2003, 21(9): 1075-1081.
  • 10Bach S, Tribouillard D, Talarek N, et al. A yeast-based assay to isolate drugs active against mammalian prions. Methods, 2006, 39(1): 72-77.

引证文献7

二级引证文献8

中国人兽共患病学报
2011年 第9期

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