两种药物联用对急性脑梗死患者神经功能及血液流变学影响的研究

Effects of Two Drugs Together Treatment of the Patients with Acute Cerebral Infarction on the Nerve Function and Blood Rheology

目的观察依达拉奉联合奥扎格雷钠治疗急性脑梗死的疗效,探讨二者对急性脑梗死患者血液流变学各指标的影响。方法 50例急性脑梗死患者随机分为观察组(常规治疗+依达拉奉联合奥扎格雷钠)及对照组(常规治疗)各25例,观察两组治疗14d后的神经功能缺损评分的变化及两组治疗前后血液流变学指标全血黏度、血浆黏度、纤维蛋白原、刚性指数、红细胞压积的变化。结果两组治疗14d后,两组患者的神经功能缺损评分比较均较治疗前明显降低,且观察组较对照组降低更明显(P<0.05)。观察组治疗后全血黏度、血浆黏度、红细胞压积、纤维蛋白原和血小板聚集率等血液流变学指标均明显改善(P<0.05)。而对照组上述指标无显著变化。结论依达拉奉联合奥扎格雷钠治疗急性脑梗死具有较好的临床疗效,能明显改善患者的血液流变学变化,改善患者的神经功能,值得推广和应用。

Objective To observe the effect of edaravone joint fasudil hydrochloride treatment acute cerebral infarction. Methods All 50 cases patients were randomly divided into observition group and control group, both groups were received conventional therapy. Observe in the conventional treatment given on the basis of edaravone and co-treatment of fasudil hydrochloride, and to compare the efficacy and neurological deficit score changes before and after treatment. Results Compared with the control group, the observation group efficiency were significantly higher than the control group （P 〈 0.05 ）. And after 14d treatment in both groups, two groups patients with neurological deficit scores were significantly lower than before treatment, and observation group were decreased more significantly （ P 〈 0.05 ）. Conclusion Edaravone joint fasudil hydrochloride treatment acute cerebral infarction with a good clinical efficacy.