轻度慢性乙型肝炎患者肝组织中HBcAg及TGF-β1的表达及临床意义

Expression and Clinical Significance of TGF-β1 and HBcAg in Chronic Hepatitis B Virus Carriers with Slight Unusual Liver Function

目的了解转化生长因子-β1(TGF-β1)和HBcAg在轻度慢性乙型肝炎患者肝组织中的表达情况。方法采用免疫组化法(S-P)检测10例对照肝组织、90例轻度慢性乙型肝炎患者肝组织TGF-β1、HBcAg的表达。结果 90例轻度慢性乙型肝炎患者肝组织TGF-β1随肝脏纤维化加重而表达增加,其差异具有显著性(P<0.05),正常肝组织组TGF-β1无表达;轻度慢性乙型肝炎患者肝组织HBcAg阳性率为81.11%,HBcAg是更可靠的HBV复制指标。结论TGF-β1、HBcAg的表达在轻度慢性乙型肝炎患者肝组织肝纤维化的形成和发展中起重要作用。TGF-β1、HBcAg的表达与早期临床诊断及治疗和判断预后密切相关。

Objective To detect the expression of transforming growth factor β1 （ TGF- β1 ） and HBcAg in chronic hepatitis B virus carriers with slight unusual liver function. Methods All the livers were detected by immunohistochemistry （ S-P ）. Results With the increase of liver fibrosis and increased expression of TGF- β1, there was significant difference （ P 〈 0.05 ）. There were no expression of TGF- β1 in normal liver tissues. The positive rate of HBcAg was 81.11% in the research group, it was more reliable copy index of HBV. Conclusion TGF- β1 and HBcAg may play an important role in the development of liver fibrosis, especially they are tightly correlated with clinical pathologic factors.