小剂量氨茶碱辅助治疗咳嗽变异性哮喘的疗效观察

Low-dose Aminophylline Assisted Treatment Cough Bariant Asthma

目的探讨小剂量氨茶碱辅助治疗咳嗽变异性哮喘的临床疗效。方法 100例咳嗽变异性哮喘患者根据所用药物的不同分为A组(n=55例,常规治疗)和B组(n=45例,在常规治疗的基础上给予小剂量氨茶碱治疗),比较两组的疗效、治疗前后哮喘发作次数以及每次发作的持续时间、肺功能的变化。结果在常规吸氧、止咳、化痰、平喘、抗炎等对症支持治疗的基础上应用氨茶碱后,B组的疗效明显优于A组(P<0.05),且B组的哮喘发作次数以及每次发作持续时间明显低于对照组(P<0.05)。B组的肺功能改善较对照组更明显(P<0.05)。结论小剂量氨茶碱辅助治疗咳嗽变异性哮喘疗效确切,能明显降低患者的发作次数以及发作时间,改善患者的肺功能,值得推广和应用。

Objective To investigate the clinical efficacy of adjuvant treatment low-dose theophylline cough variant asthma. Methods All 100 patients were divided into group A （n=55 patients, conventional treatment ） and group B （n=45 cases, on the basis of conventional therapy to give a small dose of aminophylline treatment ）. Results In normal oxygen, cough, phlegm, asthma, inflammatory, symptomatic and supportive treatment based on the application after aminophylline, B group was significantly better than group A （P 〈 0.05 ）, and number of asthma attacks and duration of each episode of group B was significantly lower than group A （P 〈 0.05 ）. Group B which improved lung function was more significantly than group A （P 〈 0.05 ）. Conclusion Low-dose theophylline assisted cough variant asthma is effective, patients can significantly reduce the number of attacks and the onset time, and to improve lung function, it should be promoted and applied.