摘要
应用大直径(10mm)环钻进行异种(牛→兔)板层角膜移植,观察时间20天。第一组(对照组):4只兔,术后7—10天全部发生了典型的排斥反应,表现有水肿,混浊和血管新生。显微镜下有大量的炎症细胞浸润。第二组:1% CsA 点眼治疗组(4只兔),2只无排斥反应,1只术后16天出现轻度排斥反应。第三组:CsA 肌肉注射组(4只兔),在观察期间均未发生排斥反应。因此,可以看出:CsA 可以:(1)抑制排斥反应;(2)延长植片存活时间;(3)抑制血管新生;(4)付作用较小。
The experiment involved the transfer of lamellar (0.3mm thick and 10mm diameter central elium with stroma)from fresh bovine eyes-onto rabbits eyes. Results:group 1,control,(4 rabbits),the donor corneas remained transparent for up to 7—10.days on the recepient rabbit eyes.After thai time,all animals in this group rejected their grafts promptly. They showed markedly circumeorneal congestion, edema and vascularization of the cornea. Histopathology:There are apparently cellular infiltration of leukocytes in the grafts and graft bed of the cornea,which are found also in the iris. Group 2:3 rabbits were treated with 1% CsA in castor oil,5 times per day.After 16 days,One of three rabbits showed mild rejection. Group 3:4 rabbits were treated with CsA,I.M. 15mg/kg/D None has any immunological response to the grafts. The histopathology of group 2 and 3 shows no cellular infiltration,except one. CsA can 1.inhibit the rejection of the heterograft.2.prglong the survive of the heterograft.3.inhibit the vascularization .4.has less side effects.
出处
《眼科学报》
CAS
1990年第3期66-72,共7页
Eye Science
