氟比洛芬酯对神经外科麻醉吸入全麻药的影响

Effects of Flurbiprofen Axetil on inhalational anesthetics in neurosurgical anesthesia

目的:观察氟比洛芬酯对神经外科幕上肿瘤切除术中吸入全麻药的影响。方法:采用随机、双盲设计,将择期行开颅小脑幕上脑肿瘤切除术、年龄18～60岁、ASA I～II级的60例患者分为生理盐水组、氯诺昔康组(16 mg)和氟比洛芬组(100 mg),每组各20例。异氟醚、舒芬太尼和维库溴铵维持麻醉,记录术中重要时间点的异氟醚浓度和肺泡最小有效浓度(MAC)。结果:氟比洛芬组在锯颅骨、剪硬膜始、骨瓣复位、缝合筋膜及缝皮时,异氟醚呼气末浓度比生理盐水组分别减少了20.3%、18.3%、18.3%、31.3%和32.2%,差异有高度统计学意义(P<0.01);MAC比生理盐水组分别减少了20.9%、21.1%、19.0%、31.0%和33.3%,差异有高度统计学意义(P<0.01)。结论:神经外科幕上脑肿瘤切除术前使用氟比洛芬酯能够减少术中吸入全麻药异氟醚的摄取。

Objective： To investigate the effects of Flurbiprofen Axetil on inhalational anesthetic consumption in supratentorial craniotomy.Methods： 60 patients（18-60 years old,ASA I-II） undergoing selective supratentorial mass resection were selected and divided into 3 groups,which were respectively titrated intravenously with normal saline（NS）,Lornoxicam（16 mg） or Flurbiprofen Axetil（100 mg） before induction,each group had 20 cases.Anesthesia was maintained with Isoflurane,Sufentanil and Vecuronium,minimal alveolar concentration（MAC） of Isoflurane and end-tidal fractional concentration were recorded at important time points.Results： Compared with group NS,in group Flurbiprofen decreased at skull opening,dura opening,skull restoring,muscle saturing and skin saturing by 20.3%,18.3%,18.3%,31.3% and 32.2%,respectively（P〈0.01）.MAC respectively decreased at 20.9%,21.1%,19.0%,31.0% and 33.3%（P〈0.01）.Conclusion： Preoperative Flurbiprofen may reduce the consumption of Isoflurane in supratentorial craniotomy.