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携带内皮抑素基因的腺病毒对HO-8910细胞裸鼠移植瘤的影响 被引量：1

Effect of Adenovirus Carrying with Endostatin Gene on HO-8910 Cells of Nude Mouse Ovarian Carcinoma
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摘要 [目的]探讨携带内皮抑素基因的腺病毒(pLP-Ad-ES)对荷人卵巢癌裸鼠移植瘤的抑制作用及其作用机制。[方法]采用细胞培养、移植瘤模型建立、RT-PCR、免疫组化等方法观察pLP-Ad-ES、pLP-Ad-ES+顺铂(DDP)对裸鼠移植瘤的影响及VEGF、MMP-2、Endostatin的表达。[结果]pLP-Ad-ES、pLP-Ad-ES+DDP能够抑制裸鼠移植瘤的生长,有明显的抑瘤作用(P<0.05);经腺病毒作用后,裸鼠移植瘤中MMP-2、VEGF呈现低表达、Endostatin呈现高表达。[结论]pLP-Ad-ES能够抑制卵巢癌裸鼠移植瘤的生长;同时能够抑制VEGF、MMP-2的表达,增强Endostatin的表达,提示内皮抑素的作用机制可能与抑制血管生成和调节基质金属蛋白酶有关。
作者 韩毅敏 王晶 隋丽华 娄阁 王玲弟
机构地区 哈尔滨医科大学附属第三医院 哈尔滨医科大学附属第二医院
出处 《中国肿瘤》 CAS 2011年第9期681-685,共5页 China Cancer
关键词 卵巢癌 腺病毒 内皮抑素 VEGF MMP-2
分类号 R73-36 [医药卫生—肿瘤]
  • 相关文献

参考文献14

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二级参考文献25

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共引文献36

同被引文献13

  • 1王忠诚.王忠诚神经外科学[M].武汉:湖北科学技术出版社,2004.475.
  • 2Yang I,Han SJ.Modern management of high grade glioma,part Ⅱ[J].Neurosurg Clin N Am,2012,23 (3):xiii-xiv.
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  • 4Boehm T,Folkman J,Browder T,et al.Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance[J].Nature,1997,390 (27):404-407.
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  • 8于音,杨洪发,邵佳甲,邬巍,朱东,姜涛,郭永川,梁前垒,李衍鑫.DAPI标记骨髓间充质干细胞在胶质瘤模型大鼠脑内的迁徙和定位[J].中国组织工程研究与临床康复,2010,14(23):4243-4246. 被引量：3
  • 9于音,赵兴利,田宇,邵佳甲,郭永川,付尧,梁前垒,李衍鑫.大鼠骨髓间充质干细胞向神经元样细胞定向诱导分化及免疫组化鉴定[J].中国实验诊断学,2010,14(7):991-993. 被引量：1
  • 10汤明芳,于健,白浪,刘琼.腺相关病毒转内皮抑素基因抑制大鼠角膜新生血管的研究[J].国际眼科杂志,2011,11(10):1695-1699. 被引量：2

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二级引证文献1

中国肿瘤
2011年 第9期

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