摘要双侧原发性乳腺癌(bilateral primary breast cancer,BPBC)的总体发病率并不高,但随着近年来乳腺癌诊断水平的提高和术后生存时间的延长,原发性双侧乳腺癌的发病率有逐年增高的趋势。本文回顾性分析我院自2006年10月至2010年12月收治的原发性双侧乳腺癌6例,全部经手术、病理证实,现就其临床特征、治疗及预后报道如下。
4Stenmark-Askmalm M , Gentile M , Wingren S , et al. Protein accumulation and gene mutation of p53 in bilateral breast cancer. South-East Sweden Breast Cancer Group [J]. Acta Oncol , 2001, 40(1): 56-62.
7Irvine T, Alien DS, Gillett C, et al. Prognosis of synchronous bilateral breast cancer [J]. Br J Surg, 2009, 96(4): 376-380.
二级参考文献32
1左文述 徐忠法.现代乳腺肿瘤学[M].济南:山东科学技术出版社,1995.155-156.
2Parkin DM, Bray F, Ferlay J, et al. Global Cancer Statistics,2002[J]. CA Cancer J Clin,2005,55(2):74-108.
3Ling Yang, D Maxwell Parkin, Jacques Ferlay, et al. Estimates of cancer incidence in China for 2000 and projections for 2005 [ J]. Cancer Epidemiol Biomarkers&Prev, 2005, 14( 1 ):243-250.
4Bardou VI, Arpino G, Elledge RM, et al. Progesterone receptor status significantly improves outcome prediction over estrogen receptor status alone for adjuvant endocrine thempy in two large breast cancer databases [J]. Jclin Oncol, 2003,21 ( 10): 1973-1979.
5Dowsettm, Harper-WynneC, Boeddinghaus I, et al. HER- 2 amplification impedes the antiprolife rative effects of hormone the rapy in estrogen receptor-positive primary breast cancer[ J].Cancer Res,2001,61 (23) :8452-8458.
7Mose S , Adanietz IA, Tnilmann C, et al. Bilateral breast carcinoma versus unilateral disease [ J ]. Am Clin Onol(CCT), 1997,20(6) :541 - 545.
8Brenner H, Engelsmann B, Stegmaier C, et al. Clinical epidemiology of bilateral breast cancer[J]. Cancer, 1993,72:3630 - 3692.
9Parnes HL, Cirrincione C, Aisner J, et al. Phase Ⅲ study of cyclophosphamide, doxorubicin,and fluorouracil (CAF)plus leucovorin versus CAF for metastatic breast cancer:Cancer and Leukemia Group B9140[J]. J Clin Oncol, 2003,21(9):1819-1824.
10SkowronekJ,Piotrowski T. Bilateral breast cancer[J]. Neoplasma, 2002, 49(1):49-54.