摘要
4例早产极低体重儿（1对女性双胞胎,胎龄31周;1对男性双胞胎,胎龄29周）于出生后22～31 d应用利奈唑胺10 mg/kg、1次/8 h静脉泵入抗感染治疗。其中例1、2为单独用药,例3同时联用利奈唑胺、美罗培南及两性霉素B脂质体,例4同时联用利奈唑胺和两性霉素B脂质体。分别于用药后4、16、8和10 d出现血小板计数下降,最低分别为27×10~9/L、74×10~9/L、23×10~9/L、4×10~9/L。停用利奈唑胺并给予对症治疗,6～17 d后血小板计数恢复正常。
Four very-low-birthweight premature infants（a pair of female twins,gestational age 31 weeks;a pair of male twins, gestational age 29 weeks.） received linezolid 10 mg/kg every 8 hours via anⅣpump for anti-infective treatment 22-31 days after birth.Patients 1 and 2 were given linezolid alone.Patient 3 was prescribed combination therapy with linezolid,meropenem,and amphotericin B liposome.Patient 4 was administered concomitant use of linezolid and amphotericin B liposome.On days 4,16,8,and 10 after drug administration,they all experienced thrombocytopenia and the minimum platelet count was 27×10~9/L,74×10~9/L,23×10~9/L,4×10~9/L,respectively.Six to seventeen days after linezolid withdrawl and administration of symptomatic treatment,their platelet count returned to normal.
出处
《药物不良反应杂志》
2011年第4期243-244,共2页
Adverse Drug Reactions Journal
