桂枝茯苓胶囊佐治痛经的疗效及对血清中超敏C反应蛋白和血管内皮生长因子影响的临床观察

Efficacy of Guizhi Fuling Capsule for Dysmenorrhea and Its Effects on C-reactive Protein and Vascular Endothelial Growth Factor:Clinical Observation

目的:研究桂枝茯苓胶囊佐治子宫内膜异位症并发痛经的效果,观察治疗前、后血清中超敏C反应蛋白(hs-CRP)和血管内皮生长因子(VEGF)的含量差别,以期为临床工作提供理论支持。方法:选取在我院确诊的210例子宫内膜异位症并发痛经的患者,按入院次序分为2组:对照组共105例,应用常规治疗;观察组共105例,在常规治疗基础上加用桂枝茯苓胶囊治疗。观察2组治疗效果的差别,并观察治疗前、后患者血清中hs-CRP和VEGF的表达差别。结果:观察组的疗效明显优于对照组,观察组治疗后血清中hs-CRP和VEGF的含量明显低于对照组。结论:在常规治疗基础上加用桂枝茯苓胶囊治疗子宫内膜异位症并发痛经,效果明显,且能有效调节血清中hs-CRP和VEGF的表达,临床中可以积极应用。

OBJECTIVE： To evaluate the efficacy of Guizhi Fuling Capsule for dysmenorrhea associated with endometriosis and its effects on serum levels of high sensitivity c reactive protein（hs-CRP） and vascular endothelial growth factor（VEGF） so as to provide theoretic support for clinical practice.METHODS： A total of 210 patients with dysmenorrhea associated with endometriosis in our hospital were assigned to either control group or trial group according to their admission order（of 105 cases each）： the control group received routine therapy while the trial group received add-on Guizhi Fuling Capsule.The curative efficacy of two groups and the serum levels of hs-CRP and VEGF before and after treatment were recorded.RESULTS： As compared with the control group,the trial group showed better efficacy and significantly lower levels of hs-CRP and VEGF in serum after treatment.CONCLUSION： Guizhi Fuling Capsule added to routine therapy had robust efficacy for dysmenorrhea associated with endometriosis and it could effectively adjust serum levels of hs-CRP and VEGF,thus the therapy is worthy of being recommended in clinical practice.