摘要
目的:探讨复方甘草酸苷联合甲氰咪胍治疗小儿过敏性紫癜(HSP)的疗效和安全性。方法:纳入HSP患儿80例,随机分为两组,对照组采用常规治疗,观察组在常规治疗基础上,加用复方甘草酸苷和甲氰咪胍治疗。结果:观察组总有效率明显高于对照组(P<0.05);观察组在皮肤紫癜消退时间、消化道症状消退时间、关节症状消退时间和肾功能改善时间明显少于对照组(P<0.05);且无不良反应发生。结论:复方甘草酸苷联合甲氰咪胍治疗小儿HSP能有效改善症状和体征、明显缩短病程、减轻关节和肾损害,临床应用安全有效。
Objective：To investigate the combined cimetidine glycyrrhizin treatment of children with Henoch - Schonlein purpura （HSP） of the efficacy and safety. Methods： HSP patients included 80 patients randomly divided into two groups, the observation group and the control group 40 cases. The control group with conventional therapy, observed in the conventional therapy group. Results： Total effective observation group was significantly higher （ P 〈 0. 05 ） , observation group in the regression time skin purpura,gastrointestinal symptoms subside time joint symptoms suhsided and renal function improved time to time was significantly less than the control group （ P 〈 0. 05 ） , and no adverse reaction. Conclusion： Compound Glycyrrhizin cimetidine treatment of children with HSP can improve the symptoms and signs, significantly shorten the course of the disease, reduce joint and kidney damage and clinical application of safe and effective.
