复发性流产患者自身抗体的检测

The detection of serum autoantibodies in patients with recurrent spontaneous abortion

目的探讨抗心磷脂抗体(ACA)、抗子宫内膜抗体(EmAb)和封闭抗体(BA)对复发性流产(RSA)诊断的意义。方法分别检测分析120例RSA患者及93例正常对照组妇女血清ACA、EmAb及BA。结果 RSA组ACA和EmAb阳性率分别为27.5%和28.3%;对照组5.4%和7.5%,两组比较差异均有统计学意义(P<0.05)。RSA组BA阴性检测率81.7%明显高于对照组12.9%,差异显著(P<0.05)。结论血清相关自身抗体检测对RSA的诊断有重要意义。

To study the diagnostic significance of anticardiolipin antibody （ACA）, anti - endometrium antibody （EMAb） and blocking antibody （BA） in patients with recurrent spontaneous abortion （RSA）. Methods ACA, EmAb and BA were detected in 120 patients with RSA and 93 healthy pregnant women. Results The positive rates of ACA and EmAb in RSA patient group were significantly higher than those in control group （27.5 % vs. 5.4 % and 28.3 % vs. 7.5 %, P 〈 0.05 ）. The negative rate of BA in RSA patient group was also significantly higher than that of control group （81.7 % vs. 12.9 %, P 〈 0.05）. Conclusion The detection of serum autoantibodies is important in diagnosis of RSA.