应用氨氯地平药动学治疗老年高血压病

The evaluation of the treatment effect of the pharmacokinetics of amlodipine on the elderly patients with hypertension

目的探讨氨氯地平的药动学理论,治疗老年人原发性高血压病二级以上患者的临床治疗效果。方法对老年人原发性高血压病二级以上患者57例,给予氨氯地平治疗10 mg,1次/d,晨间顿服,5 d后改为5 mg,1次/d,晨间顿服,疗程4周。观察患者用药前、后血压变化情况。结果本组显效45例(78.95%),有效10例(17.54%),无效2例(3.51%),总有效率96.49%,治疗4周后SBP由(160.7±19.8)mm Hg降至(130.4±9.16)mm Hg,DBP由(98.7±12.9)mm Hg降至(76.6±5.21)mm Hg。疗程结束后复查实验室指标均未出现明显变化。结论应用氨氯地平治疗老年人原发性高血压病二级以上患者,降压达标快,血压波动小,患者依从性好,用药安全性高。

Objective To investigate the treatment effect of using amlodipine＇s pharmacokinetics in the aged patient with moderate hypertension. Methods 57 cases lately in the hospital were treated by oral administration of amlodipine 10 mg once a day in the morning, and decreased to 5 mg once a day in the morning after 5 days. The treatment course was 4 weeks, and the difference of the blood pressure control was observed before and after using amlodipine. Results The total effective rate was 96.49% in the group （ excellent in 45 cases （78.95%） , valid in 10 cases （ 17.54% ） , invalid in 2 cases （3.51% ） ）. After 4 weeks treatment, the SBP decreased from （ 160.7 ± 19. 8 ） mm Hg to （ 130. 4 ±9. 16） mm Hg, while the DBP decreased from （98.7 ±12.9） mm Hg to （76.6 ±5.21 ） mm Hg. Conclusion It is faster to get a blood pressure target when use the phannacokinetics theory of amlodipine, and the influence is little in the blood pressure. The patients have a good compliance and a high safety in using the medicines.