药学干预对减少儿童抗生素相关性腹泻效果分析

Analysis of Pharmaceutical Intervention Effect on Decreasing Antibiotic Associated Diarrhea in Children

目的:探讨实施药学干预对儿童抗生素相关性腹泻(antibiotic associated diarrhea,AAD)的影响。方法:随机抽查我院2008年1月～2009年12月儿科呼吸道感染住院的病历,对AAD相关因素进行Logistic回归分析,筛选儿童AAD的危险因素,作为制定相应的药学干预措施的依据。2010年每月随机抽查儿科呼吸道感染住院的病历,对确诊为AAD的病例,采用监测-培训-计划(Monitoring-Training-Plan,MTP)干预模式进行药学干预。结果:患儿的年龄<3岁、抗生素不合理使用是我院儿童AAD的危险因素,微生态制剂应用是其保护因素。药学干预后,抗生素的使用趋向合理,AAD发生率由干预前的39.56%下降至干预后的8.52%(P<0.05),差异有统计学意义。结论:实施有效的药学干预可降低儿童AAD发生,提高治疗质量。

Objective：To investigate the influence of pharmaceutical intervention on decreasing the number of antibiotic associated diarrhea（AAD） in children.Methods： Cases of children in our hospital＇s pediatrics with respiratory infections were randomly selected from January 2008 to December 2009,for children with AAD-related factors Logistic regression analysis was performed,then the risk factors were selected for making appropriate pharmaceutical intervention measures.In 2010,cases were randomly selected every month and pharmaceutical intervention was taken for cases with AAD by Monitoring-Training-Plan（MTP） model.Results： Ages lower than 3 years and irrational use of antibiotics were risk factors of AAD.The application of probiotics was an independent protective factor of AAD.As a result of pharmaceutical intervention,the use of antibiotics tended to be rational,the incidence of AAD was significantly decreased from 39.56% to 8.52%（P0.05）.Conclusions： Effective pharmaceutical intervention could decrease the incidence of AAD and improve the quality of treatment.