92例抗生素相关性腹泻患儿的临床分析

Clinical Analysis of Antibiotic Associated Diarrhea in 92 Children

目的:探讨抗生素相关性腹泻(AAD)患儿的发生情况和相关因素。方法:统计2007年12月～2010年12月我院儿科2 502例使用抗生素的住院患儿AAD的发病率,并对导致发生AAD的主要因素进行调查、分析。结果:AAD的发病率为3.67%。AAD组病例年龄3岁以下、抗生素应用7 d以上、两种以上抗生素联用的比例明显高于未发生AAD组,两组比较差异均有统计学意义(P<0.05)。结论:儿童抗生素相关性腹泻的发病率高,与多种因素有关,规范抗生素的应用,严格控制广谱抗生素的使用,是预防控制抗生素相关性腹泻的关键措施。

Objective：To investigate the situation and related factors of antibiotic associated diarrhea（AAD） in children.Methods： Two thousand five hundred and two hospitalized children using antibiotics in our hospital from December 2007 to December 2010 were studied,and the incidence rate and main factors of AAD were investigated and analyzed retrospectively.Results： The incidence rate of antibiotic associated diarrhea was 3.67%.AAD group of patients under 3 years of age,with application of antibiotics longer than 7 days and more than two kinds of antibiotics combination,had a significantly higher proportion than non-AAD group（P0.05）.Conclusions： The incidence rate of antibiotic associated diarrhea in children is high and related with many factors.Normative application of antibiotics and rigorous control use of antibiotics are the key measures to prevent and control the antibiotic associated diarrhea.