摘要
以4-羟基-2,2,4,4-四甲基哌啶氮氧自由基为引发剂,通过ε-己内酯(ε-CL)的开环聚合反应,合成氮氧稳定自由基为末端基的聚己内酯(PCL-T);在其"介调"下,进行乙烯基吡咯烷酮(NVP)的氮氧稳定自由基聚合(NMP),得到结构规整聚己内酯和聚乙烯吡咯烷酮两亲性的嵌段共聚物(PCL-b-PNVP).通过核磁共振氢谱(1H NMR)、红外光谱(FTIR)、电子自旋共振(ESR)和凝胶渗透色谱(GPC)对聚合物的结构进行了表征.利用荧光光谱、动态光散射(DLS)、透射电镜(TEM)等手段分析共聚物自组装行为.结果表明,在聚己内酯大分子氮氧自由基"介调"下,合成了结构规整的PCL-b-PNVP共聚物,该共聚物在水中可自组装成粒径100 nm左右的核壳结构球形胶束;且共聚物表现出良好的生物相容性,可作为疏水性药物的载体材料.
Amphiphilic poly（ε-caprolactone）-block-poly（N-vinyl pyrrolidone）（PCL-b-PNVP） copolymer was synthesized by nitroxide-mediated radical polymerization of N-vinyl pyrrolidione（NVP） at the media-tion of PCL with terminated-nitroxide radical group（PCL-T）;PCL-T has been prepared by the ring-opening polymerization of ε-CL with 4-hydroxy-2,2,6,6-tetramethyl-piperidinooxy（HTEMPO） as initiator.The hy-drogen nuclear magnetic resonance（1H NMR）,electron spin resonance（ESR）,fourier transform infrared spectroscopy（FTIR） and gel permeation chromatography（GPC） were employed to characterize the structure of the polymers.The self-assembly behavior of the copolymers in aqueous media was studied by fluores-cence spectra,dynamic light scanning（DLS） and transmission electron microscope（TEM）.The results showed that the well-defined PCL-b-PNVP copolymer could be synthesized by combination of ring-opening polymerization and nitroxide-mediated radical polymerization,and the obtained copolymer could be self-assembled into well-dispersed core-shell spherical micelles with a size of 100 nm in aqueous solution.Moreover,the copolymer displayed good biocompatibility and could be acted as the hydrophobic drug car-rier.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2011年第18期2173-2178,共6页
Acta Chimica Sinica
关键词
两亲性的嵌段共聚物
聚乙烯吡咯烷酮
聚己内酯
胶束
amphiphilic block copolymer
poly（N-vinyl pyrrolidone）
poly（ε-caprolactone）
micellesAbstract：Amphiphilic poly（ε-caprolactone）-block-poly（N-vinyl pyrrolidone）（PCL-b-PNVP） copolymer was synthesized by nitroxide-mediated radical polymerization of N-vinyl pyrrolidione（NVP） at the mediation of PCL with terminated-nitroxide radical group（PCL-T）
PCL-T has been prepared by the ring-opening polymerization of ε-CL with 4-hydroxy-2
2
6
6-tetramethyl-piperidinooxy（HTEMPO） as initiator.The hydrogen nuclear magnetic resonance（1H NMR）
electron spin resonance（ESR）
fourier transform infrared spectroscopy（FTIR） and gel permeation chromatography（GPC） were employed to characterize the structure of the polymers.The self-assembly behavior of the copolymers in aqueous media was studied by fluorescence spectra
dynamic light scanning（DLS） and transmission electron microscope（TEM）.The results showed that the well-defined PCL-b-PNVP copolymer could be synthesized by combination of ring-opening polymerization and nitroxide-mediated radical polymerization
and the obtained copolymer could be self-assembled into well-dispersed core-shell spherical micelles with a size of 100 nm in aqueous solution.Moreover
the copolymer displayed good biocompatibility and could be acted as the hydrophobic drug carrier.Key words：amphiphilic block copolymer
poly（N-vinyl pyrrolidone）
poly（ε-caprolactone）
micelles
