卡贝缩宫素联合米索前列醇用于预防剖宫产术后出血的临床观察

Clinical Observation of Cabetocin Combined with Misoprostol for the Prevention of Postpartum Hemorrhage

目的:观察联合应用卡贝缩宫素与米索前列醇预防剖宫产术后出血的临床效果。方法:将2008年1月-2010年12月在我院行剖宫产的90例产妇,按单盲随机方法分为观察组52例(卡贝缩宫素+米索前列醇)和对照组38例(卡贝缩宫素)。观察比较2组治疗后的子宫收缩效果、止血效果及出血量。结果:观察组子宫收缩效果显著优于对照组(P<0.01);2组止血效果比较,观察组显效率显著优于对照组(P<0.01),而2组有效率比较差异无统计学意义(P>0.05);观察组术中、术后及总出血量均显著低于对照组(P<0.05)。结论:卡贝缩宫素联合米索前列醇预防剖宫产术后出血效果显著。

OBJECTIVE： To observe clinical efficacy of cabetocin combined with misoprostol to prevent postpartum hemorrhage. METHODS： 90 delivery women undergoing cesarean section in our hospital from Jan. 2008 to Dec. 2010 were randomly divided into observation group with 52 patients （cabetocin combined with misoprostol） and control group with 38 patients （oxytocin）. The uterine contraction effect, hemostasis effect and bleeding amount of 2 groups were observed and compared after treat- ment. RESULTS： The uterine contraction effect of observation group was significantly better than that of control group （P〈0.01） ; the effective rate of observation group were significantly better than those of control group （P〈0.01）, there was no statistical significance in the difference of effective rate between 2 groups （P〉0.05）. The intraoperatie and postoperative bleeding amount and total amount in observation group were significantly lower than in control group （P〈0.05）. CONCLUSION： Combination applica- tion of cabetocin and misoprostol in treatment of postpartum hemorrhage is effective significantly.