艾塞那肽对2型糖尿病患者的疗效观察

Therapeutic effects of exenatide in type 2 diabetic patients

目的对T2DM患者予以胰岛素联合艾塞那肽的治疗,观察艾塞那肽对T2DM的疗效。方法将入选的60例T2DM患者随机分为A组和B组,各30例。A组使用预混胰岛素治疗,B组在A组方案基础上加用艾塞那肽治疗,随访4个月,比较两组患者血糖控制、胰岛β细胞功能以及血脂、体重等变化情况。结果两组患者血糖均得到良好控制,B组△2hPG低于A组(P<0.05),△2hC-P、△HOMA-β则高于A组(P<0.05)。另外,B组患者BMI、TG较治疗前明显下降。结论使用艾塞那肽可改善T2DM患者的血糖和胰岛β细胞功能,减少胰岛素使用剂量,降低体重。

Objective To evaluate the therapeutic effects of exenatide on type 2, diabetes. Methods 60 patients with type 2 diabetes （T2DM） were randomly divided into two groups： group A （premixed insulin injection） and group B （premixed insulin plus exenatide injection）. The glucose level, cell function, lipid profiles and body weight were measured at baseline and 4 months after treatment. Results Excellent control of blood glucose was achieved in both groups. △2hPG, △2hCP, and △HOMA-β were more improved in group B than in group A （P〈0.05）. BMI and TG in group B were decreased significantly after treatment as compared with pre-treatment. Conclusions Exenatide improves glucose control and β-cell function in T2DM patients, and decreases insulin dosage and weight loss.