摘要
采用后组装法将非水溶性的治疗冠心病药物槲皮素组装进入MCM-41介孔分子筛的孔道中,药物组装率达37%[m(药物)/m(药物总量)],用XRD,扫描电镜和IR对药物组装体进行了表征;通过测定组装体在体外模拟人工小肠液中的溶出速率,表明制得了槲皮素/MCM-41缓释体系。
Using ethanol solution method to assemble non-water-soluble drug for coronary heart disease quercetin into the pores of MCM-41 ,drug-assembling rate reached 37% [ m (drug) / m ( total drug) ]. The characterization of quercetin- MCM-41 was analyzed by XRD, SEM and IR techniques, and the release rate of the assemblies was measured in the artificial intestinal fluid. The results indicated that quereetin/MCM-41 sustained-release system was established.
出处
《天然产物研究与开发》
CAS
CSCD
2011年第5期909-912,共4页
Natural Product Research and Development
基金
中央民族大学高等学校111学科创新引智计划(B08044)
中央民族大学985工程(CUN985-03-03)
关键词
MCM-41
槲皮素
组装
缓释
MCM-41
quereetin
assembing
sustained-release