不同浓度番泻叶浸剂鼻饲在食管癌术后中的临床应用

Clinical Applications of Nasal Feeding with Different Concentration Senna Infusions in Esophageal Carcinoma Post Operation

目的观察番泻叶浸剂对食管癌术后病人肠功能的促进作用,明确合适的番泻叶浸剂浓度。方法 240例食管癌术后病人随机分为5%番泻叶浸剂鼻饲组、10%番泻叶浸剂鼻饲组和白开水鼻饲组,所有病人术后经十二指肠管鼻饲白开水或番泻叶浸剂,至肠鸣音恢复。记录并比较3组病人术后肠鸣音出现时间、肛门排气、排便时间、腹痛和腹胀的发生情况、术后住院时间。结果与鼻饲白开水相比,番泻叶浸剂鼻饲可明显缩短食管癌术后病人肠鸣音出现的时间(P<0.001)、肛门排气排便时间(P<0.001),明显减少术后腹胀发生的比例(P<0.001),病人术后血清蛋白含量明显高于对照组(P=0.001);5%番泻叶浸剂鼻饲组的腹泻的发生率明显低于10%组(8.8%vs 37.5%,P<0.001)。结论番泻叶浸剂鼻饲可促进食管癌术后病人肠功能的恢复,5%的浓度在临床应用比较合适的。

Objective To explore the effects of senna infusion in promoting intestinal function of esophageal carcinoma postoperative patients, and find the appropriate concentration. Methods 240 patients of postoperative esophageal carcinoma were randomly divided into 3 groups： therapeutic group k （80 cases,nasal feeding with 5% senna infusion） ,therapeutic group B （80 cases,nasal feeding with 10% senna infusion） and experimental control group （80 cases,nasal feeding with water）. The time of bowel sounds and flatus defecation,the rate of abdominal pain and bloating in the patients were recorded and analyzed. Results Compared with plain boiled water, time of bowel sounds and flatus defecation in the patients with senna infusion nasal feeding was shorter（P 〈 0. 001 ） and the rate of abdominal pain and bloating was less（P 〈 0. 001 ）. The rate of abdominal distension in patients with 5% senna infusion nasal feeding was less than that of 10% senna infusion（8.8% vs 37.5% ,P 〈 0. 001 ）. Conclusion The senna infusion can accelerate the recovery of intestinal function in the patients of postoperative esophageal carcinoma. The 5% senna infusion is the most suitable for clinical application.