塞来昔布联合黄体酮对急性肾绞痛的观察

Study on the Acute Renal Colic Treated with Celebrex and Progesterone

目的探讨选择性COX-2抑制剂塞来昔布(西乐葆)加黄体酮对急性肾绞痛的疗效。方法采用单盲法随机给急性肾绞痛病人分成两组:观察组(n=60)以黄体酮40mg加西乐葆400mg治疗急性绞痛。对照组(n=57)以哌替啶100mg加654-2 20mg治疗绞痛。分别以15min,30min,1h,2h,观察疼痛缓解度;两组药物不良反应发生率。用药2天后血尿改变情况,采用软件SPSS 10.0统计进行方差分析。结果两组患者在2h内疼痛缓解无统计学差异(P>0.05),而不良反应与血尿缓解情况有明显统计学意义(P<0.05);观察组优于对照组。结论对于急性肾绞痛,以黄体酮联合西乐葆治疗与以哌替啶治疗效果相当,而不良反应发生率低,结石下行时间缩短,并减少结石对输尿管壁的损伤。

Objective To explore the curative effect of celebrex and progesterone for acute renal colic. Methods The cases of a- cute renal colic were divided into two groups with single blind randomization. The cases in observation group （ n = 60） were treated with celebrex 400mg and progesterone 40rag. Cases in control group（ n = 57 ） were treated with pethidine 100mg and 654 -2 20mg. Then the curative effect and side reaction after 15min,30min, 1 h,2h were observed. Meanwhile the hematuria of cases was examined in 2 days. The results were analyzed by variance （ANOVA） with SPSS 10. O. Results The odynolysis between two groups had no significant difference （P 〉 0.05 ） ,but the difference in side reaction and hematuria was significant （P 〈 0.05 ）. The therapy effect of observation group was su- pior to the control group. Conclusion For acute renal colic,celebrex and progesterone or pethidine has the same curative effect,but the former has more advantages, such as less side effect, less dropping time of calculus, and less injure ureter.