舌鳞状细胞癌浸润方式与癌淋巴管生成的特点及临床意义

The characteristics and clinical significance of lymphangiogenesis in squamous cell carcinoma of the tongue with different patterns of invasion

目的探讨不同浸润方式舌鳞状细胞癌淋巴管生成的特点及临床意义。方法 参照Anneroth等描述的肿瘤浸润方式对41例舌鳞状细胞癌进行分型,应用免疫组化法,以D2-40标记淋巴管,计数淋巴管密度(lymphatic vessel density,LVD)。结果不同浸润方式的舌鳞状细胞癌D2-40的表达不同,浸润方式为Ⅲ、Ⅳ型的舌鳞状细胞癌,淋巴管密度(LVD)显著高于Ⅰ、Ⅱ型(P<0.05),且临床易出现淋巴结转移。结论Ⅲ、Ⅳ型浸润方式的舌鳞状细胞癌恶性程度高,可能具有较强的诱导淋巴管生成的能力。

Objective To investigate the characteristics and clinical significance of lymphangiogenesis in squamous cell carcinoma（SCC） of the tongue with different patterns of invasion.Methods A total of 41 cases with squamous cell carcinoma of the tongue were classified into four groups according to the pattern of invasion and the D2-40 expression was detected using immunohistochemistry.Results The expression of D2-40 in tongue SCC varied in accordance with the pattern of invasion.The LVD in tongue SCC of pattern Ⅲ and Ⅳ invasion had a higher level than that of pattern Ⅰ and Ⅱ,with statistical significance（P0.05）.The clinical findings showed that the rate of lymph node metastasis was easily involved in pattern Ⅲ and Ⅳ.Conclusion Tongue SCC of pattern Ⅲ and Ⅳinvasion may have a strong ability to induce lymphangiogenesis.