可溶性CD83对树突状细胞体外诱导T细胞增殖的影响

Impact of soluble CD83 on dentritic cells induced T lymphocyte proliferation in vitro

目的:评价可溶性CD83(soluble CD83,sCD83)对树突状细胞(DC)体外诱导的T细胞增殖的影响。方法:采用MTT法检测DC细胞体外诱导的T细胞增殖。结果:与对照组相比,sCD83明显抑制银屑病患者DC细胞体外诱导的T细胞增殖,且与浓度呈正相关。结论:sCD83可望成为治疗银屑病的免疫抑制生物制剂。

Objective： To evaluate the impact of sCD83 on dentritic cells （DCs） induced T lymphocyte proliferation in vitro. Methods： T lymphocyte proliferation induced by dentritic cells in vitro was measured by MTT method. Results： Compared with control group, T lymphocyte proliferation induced by dentritlc cells in psoriasis patients was significantly inhibited when cultured with sCD83. Conclusions： sDC83 is possibly a potential agent in the treatment of psoriasis.