脑梗死合并代谢综合征与脑动脉粥样硬化性狭窄的关系

Relationship between cerebral artery atherosclerotic stenosis and metabolic syndrome in patients with acute cerebral infarction

目的探讨代谢综合征(MS)与脑动脉粥样硬化性病变的相关性。方法对74例因急性脑梗死入院的患者分为MS组(40例)及非MS组(34例)。借助经颅多普勒超声和(或)磁共振血管成像比较两组颅内外动脉粥样硬化性狭窄发生率。结果 MS组血管狭窄发生率为85.0%,明显高于非MS组的64.7%(P<0.05)。多元logistic回归分析示,MS与动脉粥样硬化无独立相关性,高密度脂蛋白胆固醇(HDL-C)与动脉粥样硬化独立相关(OR=0.071)。结论 MS与脑动脉粥样硬化性狭窄相关,但其危险性依赖于MS组中的低HDL-C血症。

Objective To investigate the correlation of metabolic syndrome（MS） and atherosclerotic stenosis in patients with acute cerebral infarction（ACI）.Methods A total of 74 patients with ACI was divided into MS group（40 cases） and non-MS group（34 cases）.The incidences of intra-and extra-cranial atherosclerotic stenosis were measured with transcranical Doppler（TCD） and magnetic resonance angiography（MRA）.Results The incidence of atherosclerotic stenosis was higher in MS group than that in non-MS group（85.0% vs.64.7%）（P〈0.05）.Multiple logistic regression analysis indicated that the decreased HDL-C,but not the presense of MS,was an independent risk factor for cerebrovascular stenosis（OR=0.071）.Conclusion MS is associated with atherosclerotic stenosis and the drop of HDL-C is an independent risk factor in MS patients with ACI.