杭州地区高血脂及其相关疾病的分布特征

The Distribution of Hyperlipidemia and Hyperlipemia-Related Diseases in Hangzhou Resident

目的了解高血脂及相关疾病在杭州地区成年人体检人群中的分布特征。方法 3019例体检者按性别、年龄分组,分析甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇水平,并对血脂检测结果及体检诊断结果进行统计分析。结果总胆固醇随年龄增加而增加;甘油三酯男性先增后降,女性一直增高;低密度脂蛋白胆固醇40岁以前男性高于女性(P<0.05),以后无明显差异(P>0.05);高密度脂蛋白胆固醇女性呈下降趋势,男性无变化趋势;男性高血脂检出率(59.0%)大于女性(33.5%),女性高甘油三酯、总胆固醇、低密度脂蛋白胆固醇检出率的高峰均出现在≥61岁组,男性高总胆固醇和低密度脂蛋白胆固醇检出率的高峰在≥61岁组,但高甘油三酯检出率高峰出现在41～50岁组;男性脂肪肝、高血压、糖尿病、肝内脂质沉着发生率(分别为29%、19%、8%、19%)高于女性(分别为16%、18%、6%、12%),动脉粥样硬化发生率则女性(18%)高于男性(12%);高血脂与脂肪肝、高血压、糖尿病、肝内脂质沉着的检出率呈正相关(P<0.05)。结论高血脂及其相关疾病在不同性别和年龄间的分布存在差异,只有了解高血脂及相关疾病在人群中的分布特征,才能有重点地对某些人群进行预防、及早诊断和治疗疾病,并对某些高血脂相关疾病的病因学研究提供借鉴。

Aim To understand the character of distribution for hyperlipemia and hyperlipemia-related diseases in different population. Methods 3019 people who came to our hospital for clinical exanimation were divided into groups according to their sex and age and were measured for their blood level of triglycerin（TG）,total cholesterol（TC）,high-density lipoprotein cholesterol（HDLC）,and low-density lipoprotein cholesterol（LDLC）.Then these data and clinical diagnosis were analyzed. Results The elevation of TC level was accompanied by the increase in age.In male group,the TG level was increased first followed by decrease with increase of age.However,TG level was enhanced with increase of age in female group.The level of LDLC in male group with age below 40 was significantly higher than in female counterpart（P0.05）,however,there was no statistic difference in LDLC level between male and female group with age over 40（P0.05）.Level of HDLC was decreased with the increase of age in female group,but we did not find any relation between HDLC level and age in male group.Detection rate of hyperlipidemia in male（59.0%） was higher than that in female（33.5%）,female with high TG,high TC,high LDLC detection rate peaked in the≥61 age group,male with high TC and high LDLC peak detection rate in the same group,but peak prevalence of high TG in the 41～50 age group; The high level of fatty liver,hypertension,diabetes,hepatic steatosis were more frequently found in male group（29%,19%,8%,19%）compared with female group（16%,18%,6%,12%）.In contrast,Atherosclerosis was more frequently found in female group（18%） compared with male group（12%）.It was positively correlated between hyperlipemia and fatty liver,hypertension,diabetes,hepatic steatosis（P0.05）. Conclusion The hyperlipemia and hyperlipemia-related disease were differently distributed in different population divided by age and sex.Our finding is very important for the early prevention,diagnosis and treatment of hyperlipemia and hyperlipemia-related diseases and also supplies an interesting clue for research in the cause of the hyperlipemia and hyperlipemia-related diseases.