阿维A对脓疱性银屑病患者外周血IL-8水平的影响

Effects of acitretin on the level of interleukin-8 （IL-8） in the peripheral blood of patients with pustular psoriasis

目的探讨脓疱性银屑病患者经阿维A治疗前后外周血中白介素8（IL-8）水平的变化。方法用双抗体夹心法（EuSA）检测患者治疗前、后外周血白介素（IL-8）的水平并与正常人进行比较，进一步评价IL-8与脓疱性银屑病病情的相关性。结果阿维A在改善脓疱性银屑病患者病情的同时，外周血IL-8的水平（治疗前96．84±14．68pg／ml，治疗后57．07±12．02pg／m1）显著下降，差异有统计学意义（P均〈0．05）。结论阿维A下调IL-8水平可能是其治疗脓疱性银屑病的作用机制之一。

Objective To investigate the changes of IL-8 in peripheral blood of patients with pustular psoriasis after aeitretin treatment. Methods Dual antibody sandwich enzyme-linked immunosorbent assay （ELISA） was performed to measure the IL-8 levels in the peripheral blood of 30 patients with pustular psoriasis and 30 patients with psoriasis vulgaris before and after treatment, and in 30 normal human controls. The relationship between the IL-8 level and disease severity was assessed for patients with pustular psoriasis. Results After acitretin treatment, the condition was improved greatly in patients with pustular psoriasis, together with a significant decrease in the level of IL-8 in the peripheral blood （57.07 ± 12.02 pg/ml vs. 96.84 ± 14.68 pg/ml, P 〈 0.05）. Conclusion IL-8 may be involved in the therapeutic mechanism of acitretin in pustular psoriasis.