振幅整合脑电图检查在早产儿脑成熟度评价中的应用

Role of amplitude-integrated EEG in evaluating the maturation of cerebral function in preterm infants

目的研究振幅整合脑电图检查在早产儿脑成熟度评价中的应用。方法2008年9月至2009年8月在我院NICU住院的早产儿共91例，完成振幅整合脑电图检查112例次，对图形连续性、睡眠觉醒周期及振幅的最低电压和最高电压进行分析。结果随早产儿校正胎龄的增加，图形逐渐从不连续到连续，睡眠觉醒周期逐渐规律出现，振幅最低及最高电压与校正胎龄明显相关（r=0．982，P〈0．01；r=-0．964，P〈0．01）。结论振幅整合脑电图可以作为一项简便易行的监测手段来评价早产儿脑成熟度。

Objective To investigate the efficacy of amplitude-integrated electroencephalographic （aEEG） in evaluating the maturation of cerebral function in preterm infants. Methods Ninety one neurolog- ically normal and clinically stable preterm infants admitted to neonatal intensive care unit were studied pro- spectively by using aEEG. Background of aEEG activity patterns, presence of sleep-wake cycles, and the low- er and higher border were analyzed. Results 112 aEEG were analyzed. The sleep-wake cycle and the continuity became more mature with PMA increased. The lower border were increased and the higher border were decreased with PMA increased（ r = 0. 982, P 〈 0. 01 ; r = - 0. 964, P 〈 0. 01 ）. Conclusion In preterm infants, aEEG is a useful tool to evaluate the maturation of cerebral function.