播散性马尔尼菲青霉菌感染二例报道并文献复习

Disseminated penicillium marneffei infection： two case reports and review of literature

目的探讨儿童播散性马尔尼菲青霉菌感染的实验室检查、临床表现和治疗策略。方法报道分析播散性马尔尼菲青霉菌感染患儿临床表现，病原学检查，影像学资料和治疗结果。结果病例1，男，1岁，发热、咳嗽1个月；骨髓、血培养：马尔尼菲青霉菌；伏立康唑治疗后好转。病例2，女，8岁，发热1个月，烦躁1d；血培养：马尔尼菲青霉菌。结论儿童播散性马尔尼菲青霉菌感染可累及中枢神经系统。伏立康唑可作为静脉一口服序贯治疗策略的选择。

Objective To discover the clinic presentation and therapy of disseminated Penicillium marneffei infection in children. Methods We reported the clinic presenation, pathology and therapy of the disseminated Penicillium marneffei in children. Results Case one, 1-year-old boy presented with fever and cough for one month. Penicillium mameffei was cultured from bone marrow and blood. Case two, 8-year-old girl presented with delirium. Penicillium marneffei was cultured from blood. Treatment with voriconazole solely was successful in the first case. Conduslon Central nervous system could been infected by Penicilli- um marneffei. Treatment with voriconazole solely could be effective in children.