多模式分子影像PET-MRI的研究进展

Progress in PET-MRI multimodality molecular imaging

PET-CT已成为当今恶性肿瘤诊断、分期及疗效评价必不可少的工具，但是，MRI具有比CT更好的软组织分辨力，还可提供多种生理功能、多序列和多参数成像，且无放射性损伤，其与PET提供的分子信息互补、融合，有望成为新的双模式显像工具，在基础和临床研究中将起着至关重要的作用。然而PET与MRI结合在技术上具有很多挑战，近几年来成为分子影像学研究的热点，并已取得了重大进展。该文对PET-MRI融合技术及设备、初步应用及多模式探针的研究进展等作相关综述。

PET-CT muhimodality imaging has become an essential tool for diagnosis, staging and therapeutic evaluation for malignancy. But MRI has better soft tissue resolution than CT, and provides a variety of functional imaging, multi-sequence and muhi-parameter imaging, and has no radiation damage. The integration of plentiful information from MRI and molecular information provided by PET is expected to become a new dual-mode imaging tool which will play a very important role in basic and clinical research. However, many challenges are existed in the combined PET and MRI technology, and it has become a focus in molecu- lar imaging research in recent years, and has made significant progress. This paper overviews the progresses of PET-MRI integration technologies and devices, preliminary applications and multimodality probes.