微波辅助三分子点击化学合成1,4-二取代-1,2,3-三氮唑衍生物

A microwave-assisted three molecule click chemistry synthesis of 1,4-disubstituted-1,2,3-triazole derivatives

三氮唑是一类重要的有机化合物.本文用点击化学合成了1,4-二取代-1,2,3-三氮唑衍生物.在微波辅助下,碘化亚铜催化叠氮化钠、炔烃、苯磺酸酯三组分反应合成了一系列1,4-二取代-1,2,3-三氮唑衍生物.控制微波功率65～80W,温度50～75℃,反应在15min内完成,产率81%～94%.新化合物结构用红外、1 H-NMR、13 C-NMR、DEPT、HR-MS、元素分析鉴定.实验结果表明该方法条件温和,操作简单,对环境友好.

Triazole is an important organic compound. In this article, we synthesised 1, 4-disubstituted-1,2, 3-triazole derivatives with click chemistry. A microwave-assisted three-component reaction was used to prepare a series of 1,4-disubstituted-1,2,3-triazoles from corresponding sodium azide, alkynes and benzene sulfonates via CuI catalyzed. Controling microwave power 65-80 W, temperature 50-75℃, the reaction was completed in 15 min, the yield of 81-94%. The structure of new products（e-p） was confirmed by IR.^1H NMR.^13C NMR.DEPT.HR-MS.elementary analysis. The results indicated that the reaction simple and under mild conditions, and it was environmentally friendly.