112株新生儿感染金黄色葡萄球菌药敏分析

Drug sensitive analysis of 112 strains of Staphylococcus aureus

目的了解金黄色葡萄球菌(SAU)的临床分布及其耐药性,为临床合理用药提供依据。方法对2008年1月至2009年12月湖南省儿童医院临床分离的112株新生儿感染SAU的分布及耐药情况进行回顾性分析。结果 112株SAU主要分离自呼吸道标本(65.18%),SAU对青霉素、阿莫西林、克林霉素及红霉素耐药率高,耐甲氧西林金黄色葡萄球菌(MRSA)20株,占17.86%。甲氧西林敏感金黄色葡萄球菌(MSSA)耐药率明显低于MRSA。所有菌株均对万古霉素和利奈唑烷敏感。结论 SAU主要分布于痰标本,其分离株对青霉素、阿莫西林、克林霉素和红霉素的耐药率高,而对头孢菌素和头孢西丁有相对较高的敏感性,儿科应加强对SAU的监测,并合理选择抗菌药物。

Objective To investigate the clinical distribution and antimicrobial resistance of Staphylococcus aureus（SAU） and provide guidance for clinical use of the drug in reasonable way.Methods We retrospectively analysis clinical distribution and antimicrobial resistance of SAU,which isolated from 112 newborn of Hunan Children′s Hospital from Jan.2008 to Dec.2009.Results Most of the 112 SAU strains were isolated from respiratory tract（65.18%）,Resistance rate of SAU to penicillin amoxicillin,Clindamycin and erythromycin were high.Methicillin-resistant staphylococcus aureus（MRSA） was 20 strains（17.86%）.Resistance of Methicillin-sensitive Staphylococcus aureus（MSSA） was significantly lower than MRSA,All the strains were sensitive to vacomycin and linezoid.Conclusion SAU has strong resistance to penicillin amoxicillin,Clindamycin and erythromycin,but relative sensitive to oxacillin and cephalosporin.Pediatrics should strengthen the monitoring and use of the antibiotics in reasonable way.