摘要
目的探讨酒精性脂肪肝患者血浆瘦素(Leptin)和血清白细胞介素-1、白细胞介素-18、脂联素(ADP)水平的变化及临床意义。方法应用放射免疫分析法和酶联免疫吸附试验对37例酒精性脂肪肝患者血浆Leptin和血清IL-1、IL-18及ADP水平进行测定,并与34例健康对照者比较。结果酒精性脂肪肝患者血浆Leptin和血清IL-1、IL-18水平均显著高于健康对照组(P<0.01),而血清ADP水平又明显低于健康对照组(P<0.01),血浆Leptin水平与IL-1、IL-18水平呈正相关(r=0.587 2,0.613 4,P<0.01),而与ADP水平呈负相关(r=-0.478 4,P<0.01)。结论检测酒精性脂肪肝患者血浆Leptin和血清IL-1、IL-18和ADP水平的变化可以作为辅助诊断脂肪肝及判断其肝损伤严重程度的一个检测指标,有重要临床价值。
Objective To explore the significame of level changes of plasma leptin and serum IL-1,IL-18 and adiponection（ADP） in patients with alcohol fatty liver.Methods The levels of plasma leptin,serum IL-1,IL-18 and ADP in 37 patients with alcohol fatly liver and 34 health controls were measured by RIA and ELISA.Results The levels of plasma leptin and serum IL-1,IL-18 in patients with alcohol fatly liver were significantly higher than those of controls（P0.01）.While the serum ADP level was signifiicamt lower than that of controls（P0.01）.The plasma Leptin levels were positively correlated with IL-1,IL-18（r=0.587 2,0.613 7,P0.01）and negatively correlated with ADP（r=-0.478 4,P0.01）.Conclusion The detection of plasma leptin and seram IL-1,IL-18 and ADP levels in patients with alcohol fatty liver diseases has an important value on diagnosis of fatty liver and the severity of liver injury.
出处
《检验医学与临床》
CAS
2011年第19期2329-2330,共2页
Laboratory Medicine and Clinic
