儿童哮喘症与白细胞介素的相关性研究

The research of the relevance between asthma and interleukin of children

目的进一步探讨儿童哮喘症与白细胞介素-1(IL-1)、IL-5、IL-12、IL-13的相关性,为临床预防和治疗儿童哮喘症提供理论依据。方法儿童哮喘症患儿50例,男32例,女18例,平均年龄(3.26±1.3);儿童哮喘症患儿又分为急性发作期组30例和缓解期组20例。健康对照组40例,男20例,女20例,平均年龄(3.87±1.56)。采用酶联免疫吸附试验法检测血清IL-1、IL-5、IL-12、IL-13水平。结果哮喘症患儿IL-1、IL-5、IL-13较健康对照组明显升高,IL-12水平较健康对照组明显降低,差异有统计学意义(P<0.05)。结论儿童哮喘症患儿存在着IL-1、IL-5、IL-12、IL-13的增高和紊乱。

Objective To further explore the relevance between children with asthmatic and interleukin 1,5,12,13,in order to provide theory basis for the clinical prophylaxis and treatment asthmatic children.Methods 50 cases of children with asthma,in which there were 32 male cases,18 female cases,with the average age of 3.26±1.3.Asthmatic children were divided into the acute episode group with 30 cases and the remission group with 20 patients and the normal control group with 40 cases including 20 male and 20 female patients（mean age 3.87±1.56）.Then the serum interleukin 1,5,12,13 levels were detected by ELISA method.Results The serum interleukin 1,5,13 level increased significantly compared with the control group.IL-12 level is significantly lower than the normal control group（P0.05）..Conclusion Increase and disorder of interleukin 1,5,12,13 exist in asthmatic children.