正交法优化氯甲基试剂BCMB合成条件的研究

Study on optimization of synthesis conditions of chloromethylation reagent (BCMB) by orthogonal method

以l,4—丁二醇为原料,通过均相法合成了氯甲基化试剂1,4—二氯甲氧基丁烷(BCMB)并用红外光谱(IR)对产物进行了表征.采用正交试验法,考察了反应时间、反应温度、液料比三个因素对BCMB得率的影响.较佳的合成条件是:反应时间4小时,反应温度是20摄氏度,液料比是3:1时,产物的得率为80%.

The chloromethylation reagent1,4-bis（chloromethoxyl） butaneas（BCMB） is synthesized with l,4-butyl glycol as a raw material,through homogeneous.The product is characterized by infrared spectroscopy（IR）.Orthogonal experimental method is used to obtain the optimal reaction time,temperature,and the ratio solvent to material.The suitable condition of synthesis is as follows：reaction time 4 hours,temperature is 20 degrees Celsius,the ratio of liquid to material 3：1.The yield is about 80%