摘要
抗苗勒管激素(anti-müllerian hormone,AMH)是转化生长因子β超家族的成员,在女性中仅表达于卵巢的颗粒细胞,可用于评估卵巢的储备功能。其有Ⅰ～Ⅲ型受体,现已明确人类的AMH通过其Ⅱ型受体(AMHRⅡ)发挥作用。目前多囊卵巢综合征(PCOS)、卵巢功能早衰(POF)是引起育龄期妇女不孕的主要原因。AMH在PCOS患者血清中浓度较高;而在POF患者血清中浓度较低,甚至检测不到;在性早熟(PA)患儿血清中的浓度接近正常。研究发现,AMH及AMHRⅡ的基因多态性与PCOS和POF的发病密切相关。AMH可作为PCOS,POF和PA等疾病的诊断依据,并可指导PCOS患者的临床治疗。
Anti-Müllerian hormone（AMH）,a member of the transforming growth factor（TGF-β） superfamily,mainly expressed in the granulosa cells of ovarian in women,which can be used as a marker to evaluate the ovarian reserve.There are three types of AMH receptor,Ⅰ,Ⅱ and Ⅲ type.In human,AMH acts via receptor Ⅱ.PCOS and POF are the main reason of infertility.It was found that sera AMH was at high level in PCOS,at low level in POF,but at almost normal level in precocious puberty.AMH,as well as its receptor Ⅱ,gene polymorphisms are related with PCOS and POF.AMH may be an important marker for the diagnosis of PCOS,POF,PA,and it also be a guided marker for PCOS treatment.
出处
《国际生殖健康／计划生育杂志》
CAS
2011年第5期397-400,共4页
Journal of International Reproductive Health/Family Planning
基金
宁夏自然科学基金资助项目(NZ10115)
银川市2010年第一批科技项目(2010452)
关键词
抗苗勒管激素
多囊卵巢综合征
卵巢功能早衰
青春期
早熟
Anti-mullerian hormone
Polycystic ovary syndrome
Ovarian failure
premature
Puberty
precocious
