利培酮对精神分裂症患者执行功能的影响

Effection of executive function in schizophrenic patients treated with Risperidone

目的探讨利培酮对精神分裂症患者执行功能的影响。方法对83例精神分裂症患者进行利培酮（3~6mg.d-1）治疗8周,治疗前后进行威斯康星卡片分类测验（WCST）、阳性与阴性症状量表（PANSS）测验,并与65例正常人对照。结果治疗前治疗组与正常对照组在反映前额叶执行功能WCST指标的比较,治疗组WCST中各项指标测验成绩均较对照组差（P〈0.05或P〈0.01）。利培酮治疗前后治疗组WCST测验成绩除了分类数、正确数和非持续错误数无统计学意义外,错误数、持续错误数测验分数均较治疗前明显下降（P〈0.01）;阳性与阴性症状量表分数均明显降低（P〈0.01）。结论精神分裂症患者存在执行功能障碍,利培酮对精神分裂症患者的执行功能有改善作用。

OBJECTIVE To explore the effects of Risperidone on executive function in schizophrenic patients.METHODS Compare the scores of Wisconsin Card Sorting Test（WCST）and Positive and Negative Syndrome Scale（PANSS）between 83 schizophrenic patients treated with Risperidone（3～6mg·d-1）for 8 weeks and 65 normal persons as controls.RESULTS Before treatment the WCST scores of patients are lower than controls significantly（P0.05,P0.01）.In comparerison the patients and the controls,there are significant differences between before treatment and after treatment with Risperidone in patients except Categories Complets,Right Scores and Random Errors,Total Errors,Preservative Errors are lower than before treatment.Scores of PANSS are siginificant lower after treatment.CONCLUSION There are executive function disorder in schizophrenic patients.The Risperidone is useful for treatment of schizophrenia′s excutive function.