单纯夜间高血压患者超氧化物歧化酶、丙二醛与超敏C反应蛋白的水平变化

The changes of malondialdehyde,superoxide dismutase and high-sensitivity C-reactive protein in patients with isolated nocturnal hypertension

目的探讨单纯夜间高血压(isolated nocturnal hypertension,INH)患者体内丙二醛(malondial-dehyde,MDA)、超氧化物歧化酶(superoxide dismutase,SOD)与超敏C反应蛋白(high-sensitivity C-reactiveprotein,hs-CRP)的变化。方法选取诊所血压正常的健康体检者110例,均行24 h动态血压(ABP)检查,根据ABP检测结果将其分为单纯夜间高血压组(INH组)40例和正常对照组(NBP组)70例,并对比分析两组血浆hs-CRP、SOD及MDA。结果 INH组hs-CRP和MDA水平明显升高、SOD明显降低,与NBP组比较有统计学意义(P均<0.05)。结论 INH患者体内存在异常的氧化应激及炎症反应,两者可能参与了INH的发病过程与进展。

Objective To study the changes of malondialdehyde（MDA）,superoxide dismutase（SOD） and high-sensitivity C-reactive protein（hs-CRP） in patients with isolated nocturnal hypertension（INH）.Methods One hundred and ten subjects with normal clinic blood pressure（CBP） were divided into two groups according to the results of ambulatory blood pressure monitoring（ABPM）：patients with isolated nocturnal hypertension（n=40） and healthy control（NBP,n=70）.The MDA、SOD、hs-CRP were measured and assessed.Results In patients with isolated nocturnal hypertension,the MDA、hs-CRP levels were significantly higher than that in the control group（P0.05）,but the SOD level was lower（P0.05）.Conclusion There were abnormal oxidative stress and inflammation in patients with masked hypertension.