四物汤抗痛经作用的组方配比研究

Study on Prescription Ratio of Si-wu Decoction in Treating Dysmenorrhea

目的:探讨四物汤抗痛经作用的最佳组方。方法:用四因素三水平的正交试验以小鼠痛经模型为指标,评价抗痛经作用。结果:在四物汤中,当归抗小鼠痛经作用的药效水平3(12 g)显著高于水平1(3 g)和2(6 g),川芎水平3(9 g)与水平1(3 g)和2(6 g)相比有增强趋势;熟地黄、白芍的3个水平的药效几乎在同一水平。结论:四物汤抗痛经组方的最佳配比选为当归12 g,川芎9 g,白芍6 g和熟地黄9 g。

Objective：To investigate the best prescription ratio of siwu decoction in treating dysmenorrhea.Methods：The four-factor and three-level orthogonal experiment regarded dysmenorrhea model of mice as an indicator to evaluate anti-dysmenorrhea effect.Results：Among siwu decoction,the efficacy of level 3（12 g） of angelica in treating dysmenorrhea was significantly higher than that of level 1（3 g） and level 2（6 g）.Compared with level 1（3 g） and level 2（6 g）,level 3（9 g） of rhizome showed an increasing trend;the efficacy of three levels of rehmannia and white peony root were almost in the same level.Conclusion：The best prescription ratio of siwu decoction in treating dysmenorrheal was angelica 12 g,rhizome 9 g,white peony root 6 g,and rehmannia 9 g.