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紫杉类药物的研发现状及治疗卵巢癌的研究进展 被引量:13

Taxanes:Research Status and Chemotherapy of Ovarian Cancer
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摘要 本文聚焦紫杉类药物在卵巢癌化疗中的研究与应用现状。结合紫杉类药物结构及剂型改造,阐述各种紫杉类药物在卵巢癌化疗中的应用。结构改造与剂型优化后的紫杉类制剂已在卵巢癌化疗中广泛使用。尚需更多的临床试验,为紫杉类药物的合理使用提供依据。 Review the taxanes used in the chemotherapy of ovarian cancer. Based on the progress both in the structure and the formulation, we elaborate the application of the taxanes used in the chemotherapy of ovarian cancer. The taxanes which got the progress in the structure and the formulation have been used in the chemotherapy widely. We need more clinical trials to provide the evidence that taxanes could been used rationally.
出处 《中华妇幼临床医学杂志(电子版)》 CAS 2011年第5期396-400,共5页 Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)
关键词 紫杉类药物 卵巢癌 化疗 taxane ovarian cancer chemotherapy
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参考文献33

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二级参考文献2

  • 1Xiaokui Yang,Fang Zheng,Hui Xing,Qinglei Gao,Wang Wei,Yunping Lu,Shixuan Wang,Jianfeng Zhou,Wei Hu,Ding Ma. Resistance to chemotherapy-induced apoptosis via decreased caspase-3 activity and overexpression of antiapoptotic proteins in ovarian cancer[J] 2004,Journal of Cancer Research and Clinical Oncology(7):423~428
  • 2Refika I. Pakunlu,Thomas J. Cook,Tamara Minko. Simultaneous Modulation of Multidrug Resistance and Antiapoptotic Cellular Defense by MDR1 and BCL-2 Targeted Antisense Oligonucleotides Enhances the Anticancer Efficacy of Doxorubicin[J] 2003,Pharmaceutical Research(3):351~359

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