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肿瘤坏死因子α对链脲佐菌素糖尿病大鼠血压的影响

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摘要 ①目的探讨肿瘤坏死因子α(TNF-α)对实验性糖尿病大鼠血压的影响。②方法 SD大鼠随机分出观察组及预防组、对照组,并予高脂饲料加链脲佐菌素(Streptozotocin,STZ),建立糖尿病大鼠模型。第3周始,预防组大鼠以皮下注射方式予TNF-α受体抗体。给药结束后测定大鼠收缩压(SBP)、舒张压(DBP),并取血进行空腹血糖(FBG)检测。③结果与观察组相比,预防组大鼠收缩压明显下降,差别具有统计学意义。④结论 TNF-α与糖尿病大鼠血压的上升具有一定的相关性。
出处 《华北煤炭医学院学报》 2011年第5期606-607,共2页 Journal of North China Coal Medical College
基金 皖南医学院中青年科研基金(编号:WK201016)
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