摘要
目的:分析丙泊酚对急性颅脑损伤患者体内活性氧的消除作用及效果。方法:分别采用电子自旋共振法及化学发光-高效液相色谱法,测定43例急性颅脑损伤患者手术前后血内氧自由基,一氧化氮、脂质过氧化物含量,分析丙泊酚对急性颅脑损伤患者体内活性氧的清除作用及效果。结果:除开颅去骨瓣2 h一氧化碳检测均值外,开颅手术去骨瓣2 h及4 h各项指标与麻醉诱导前相比均有显著性降低,差异均有统计学意义(P≤0.05)。结论:丙泊酚能够有效清除急性颅脑损伤患者体内活性氧,降低继发性脑缺血再灌注损害的发病风险。
Objective：In order to investigate the elimination effect and curative effect of propofol on reactive oxygen species in patients with acute craniocerebral injury. Method：We used electron spin resonance spectroscopy to determine the plasma contents of oxygen free radical,and the chemical-high performance liquid chromatography were used to determine the nitrogen oxide and plasma contents of lipid peroxides.And then investigated the elimination effect and curative effect of propofol on reactive oxygen species in patients with acute craniocerebral injury. Result：Except of the nitrogen oxide in 2 hours after starting operation,every indexes in 2 and 4 hours after starting operation were lower,there were difference between the performance（P0.05）. Conclusion：Propofol can clear the reactive oxygen species in patients with acute craniocerebral injury,and lessen the risk of secondary cerebral injury.
出处
《河北医学》
CAS
2011年第10期1301-1303,共3页
Hebei Medicine
关键词
丙泊酚
急性颅脑损伤
活性氧
Propofol
Acute craniocerebral injury
Reactive oxygen species
