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维生素D补充与药物选择 被引量：6

Vitamin D supplementation and its supplements selection
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摘要 近10多年来,液相色谱-质谱法(LC-MS)已能精确区分且定量测定血清25-羟基维生素D2(25(OH)D2)和25-羟基维生素D3(25(OH)D3)水平,由此发现维生素D3的营养能力优于维生素D2。本文介绍用25-羟基维生素D水平评估维生素D营养状况的理由及定量测定25(OH)D2和25(OH)D3方法的演变过程,综述比较维生素D2和维生素D3提高血清25(OH)D2和25(OH)D3水平能力的临床数据,并得到如下结论:为了预防和治疗维生素D不足或缺乏,临床医师应该首选维生素D3补充剂。 LC-MS has been able to accurately distinguish and quantify serum levels of 25（OH）D2 and 25（OH）D3 over the last decade.It is found that the nutritional effects of vitamin D3 are better than those of vitamin D2.This article describes the reasons for using 25（OH）D as assessment for nutritional status of vitamin D and an evolution of quantitative determination of 25（OH）D2 and 25（OH）D3 levels,and reviews clinical research data on improvement of 25（OH）D2 and 25（OH）D3 levels in serum by supplementation of vitamin D2 and vitamin D3.Therefore,clinicians should prefer vitamin D3 supplements in order to prevent and treat vitamin D insufficiency and deficiency.
作者 周建烈 杨宗麟
机构地区 <今日维生素D>网站 南加州大学化学系
出处 《上海医药》 CAS 2011年第10期472-474,共3页 Shanghai Medical & Pharmaceutical Journal
关键词 维生素D2 维生素D3 25-羟基维生素D2 25-羟基维生素D3 vitamin D2 vitamin D3 25（OH）D2 25（OH）D3
分类号 R151.41 [医药卫生—营养与食品卫生学] R977.24 [医药卫生—药品]
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参考文献17

  • 1Mistretta VI,Delanaye P,Chapelle JP,et al.Vitamin D2 or vitamin D3?[J].Rev Med Interne,2008,29(10):815-820.
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同被引文献74

  • 1Lips P. Relative value of 25 (OH) D and 1, 25 (OH)2Dmeasurements [ J ]. J Bone Miner Res,2007,22 ( 11 ):1668-1671.
  • 2Seamans KM,Cashman KD. Existing and potentially novelfunc-tional markers of vitamin D status: A systematic review [ J ].Am J Clin Nutr, 2009, 89 (6): S1997-S2008.
  • 3Kavathia D, Buckley JD, Rao D,et al . Elevated 1 , 25-di-hydroxy vitamin D levels are associated with protracted treatmentin sarcoidosis [ J]. Respir Med, 2010,104 (4) : 564-570.
  • 4Zerwekh JE. Blood biomarkers of vitamin D status [ J]. Am JClin Nutr, 2008, 87 (4): S1087-1091.
  • 5Wang S. Epidemiology of vitamin D in health and disease [ J] .Nutr Res Rev, 2009, 22 (2): 188-203.
  • 6Holick MF. Vitamin D deficiency [J]. N Engl J Med, 2007,357 (3) : 266-281.
  • 7Dror DK, Allen LH. Vitamin D inadequacy in pregnancy: biol-ogy, outcomes, and interventions [ J]. Nutr Rev, 2010,68(8): 465-477.
  • 8Holick MF, Binkley NC, Bischof-Ferrari HA, et al. Evalua-tion, treatment, and prevention of vitamin D deficiency : anEndocrine Society clinical practice guideline [ J ]. J Clin Endo-crinol Metab, 2011,96 (7) : 1911-1930.
  • 9Hollis BW, Wagner CL. Nutritional vitamin D status duringpregnancy : reasons for concer [ J] . CMAJ, 2006, 174 (9):1287-1290.
  • 10Bodnar LM, Simhan HN, Powers RW, et al. High prevalenceof vitamin D insufficiency in black and white pregnant women re-siding in the northern United States and their neonates [ J]. Nu-tr, 2007,137 (2) : 447-452.

引证文献6

二级引证文献76

上海医药
2011年 第10期

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